Presence in Tumor Tissue of a Mouse Mammary Cancer Accelerant.

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Abstract
An accelerating factor was demonstrated in the unfiltered supernatant fluid which had been prepared by centrifugation repeatedly of a saline extract of fresh mouse mammary carcinoma Z8352. This tumor was obtained from a female C3H mouse possessing the milk agent and maintained by transplantation in ZBC mice which presumably were free of mammary cancer virus. These findings were extended in a 2d series of 3 expts. involving 102 ZBC mice by the demonstration of a similar accelerant in homogenates of Z8352 tumor tissue which had been stored in a deep freeze chest at -18[degree]C for 63-118 days. The "fresh accelerant" and the "frozen accelerant," are probably a single entity derived from the mammary tumor tissue by 2 different methods. The presence of an accelerating factor in frozen homogenates of tumor tissue suggests the "XYZ factor" demonstrated by Casey in the Brown-Pearce rabbit tumor. However, these findings are notably different, for the presence of an accelerant factor is made known for fresh supernatant fluid from a different tumor in a different host species.

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