Is the coagulopathy of hepatosplenic schistosomiasis immune-related?

Publisher Website
Google Scholar
Abstract
Some of the soluble factors that affect haemostasis produced in the course of hepatosplenic schistosomiasis, including endotoxins (Ex), interleukin-1α (IL-1α) and tumour necrosis factor-α (TNF-α) were studied. Forty-one patients with hepatosplenic schistosomiasis were studied and classified into early hepatosplenic schistosomiasis (n = 12), hepatocellular decompensation (n = 14), vascular decompensation (n = 15) as well as twelve healthy controls. Thrombin-antithrombin complex (TAT), protein C and free protein S antigen and activity, endotoxin, IL-1α and TNF-α levels were measured in all cases. Evidence of enhanced thrombin generation (elevated TAT levels) with reduced anticoagulant potential (reduced protein C and free protein S antigen and activity levels) could be demonstrated, thus reflecting decreased production and increased consumption of both coagulant and anticoagulant proteins. The association of high Ex, IL-1α and TNF-α levels may suggest their possible implication in the causation of intravascular coagulation in hepatosplenic schistosomiasis.

This publication has 0 references indexed in Scilit: