The bactericidal activity of various aminoglycoside antibiotics against Mycobacterium leprae in mice

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Abstract
The killing potential of various aminoglycoside antibiotics for M. leprae infection of the mouse footpad was studied, utilizing daily i.p. therapy. Kanamycin (100 mg/kg), streptomycin (150 mg/kg) and amikacin (100 mg/kg) resulted in impressive killing of bacilli (99.7%, 97% and 96% bactericidal, respectively). Gentamicin (20 mg/kg) and tobramycin (20 mg/kg) were much less active (60% and 37% bactericidal). The bactericidal activity of these very high doses of kanamycin, streptomycin and amikacin compared favorably with those of other agents previously studied in a similar manner at relatively lower dosage levels.