Prostaglandin E1 infusion in newborns with hypoplastic left ventricle and aortic atresia

1 June 1982

journal article
Published by Springer Nature in Pediatric Cardiology

Vol. 2 (2) , 95-98
https://doi.org/10.1007/bf02424943

Abstract

Prostaglandin E₁ (PGE₁) infusion was used in 7 infants with hypoplastic left ventricle and aortic atresia. Of 5 non-operated patients, 4 died shortly after the onset of PGE₁ infusion and 1 survived for 30 hours. Of the 2 infants who had surgery, 1 died during the operation and 1 survived for 38 days. In 6 infants, a transient metabolic and/or circulatory improvement could be demonstrated following PGE₁ infusion. The lack of response of other infants may be related to the advanced deterioration of their clinical status at the time of study. In the light of recent surgical developments for infants with aortic atresia, support with PGE₁ may nevertheless play an important role in their management if started early.

Keywords

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