EXPERIMENTAL PSEUDOMONAS PNEUMONIA IN LEUKOPENIC DOGS - COMPARISON OF THERAPY WITH ANTIBIOTICS AND GRANULOCYTE TRANSFUSIONS
- 1 January 1976
- journal article
- research article
- Vol. 47 (5) , 869-876
Abstract
P. aeruginosa pneumonia was produced in dogs with radiation-induced leukopenia to study the comparative efficacy of several different therapies. In a randomized control trial, 5 treatment regimens were compared: no antibiotics or granulocytes (controls) gentamicin (5 mg/kg per day), carbenicillin (500 mg/kg per day), gentamicin and carbenicillin (same dosages), and daily granulocyte transfusions (minimum 5 .times. 109 cells/day) plus gentamicin (5 mg/kg per day). The most effective therapy was gentamicin plus granulocyte transfusions. Gentamicin alone was not significantly better than no specific therapy. Carbenicillin with or without gentamicin gave intermediate results. This study further supports the utility of granulocyte replacement therapy of infections in severely granulocytopenic subjects and indicates that the relative value of granulocyte transfusions depends upon the specific antibiotic regimen with which these transfusions are compared.This publication has 1 reference indexed in Scilit:
- Pseudomonas aeruginosa Infections: Persisting Problems and Current Research to Find New TherapiesAnnals of Internal Medicine, 1975