THE RELATION OF IMMUNITY TO THE EXPERIMENTAL PRODUCTION OF ABSCESS OF THE LUNG

Publisher Website
Google Scholar
Abstract
The authors had previously demonstrated that when an artificial ernbolus composed of a segment of vein filled with blood and bacteria was freed into the jugular vein of a dog it resulted in a true abscess of the lung at the point of lodgement. This extends the original study by an attempt to study what effect immunity plays in the type of lesion produced. In the 1st series of tests resistance was varied by artificial vaccination. When clots of equal virulence were freed into the individuals it was apparent that animals with high resistance were able to remain free of suppurative process; unaltered animals showed abscess. In the 2nd series an infected clot was manufactured in vivo, a segment of vein being exposed, traumatized and its contents infected. Virulence of this clot was attenuated by residence in the animal before being freed, its attenuation increasing with time. Using normal animals of presumably equal resistance, it was found that the resulting lesions in the lungs, when these clots were freed into the jugular vein, varied with the time over which the organisms were attenuated. These experiments would seem to indicate that lesions resulting from infected emboli depend both on resistance of host and virulence of infecting organism.

This publication has 0 references indexed in Scilit: