Intolerance to Aspirin
- 1 May 1968
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 68 (5) , 975-983
- https://doi.org/10.7326/0003-4819-68-5-975
Abstract
The clinical history of more than 1000 aspirin-sensitive patients who have been under observation from 1954 until 1965 is analyzed. Administration of various salicylate esters confirms the unique effect of the acetyl ester; several chemically unrelated analgesics, produce reactions as severe as the reactions caused by aspirin. Intolerance to aspirin may be caused by the pharmacological action of the drug on peripheral chemoreceptors.Keywords
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