Protein intrinsic disorder toolbox for comparative analysis of viral proteins
Open Access
- 1 January 2008
- journal article
- research article
- Published by Springer Nature in BMC Genomics
- Vol. 9 (Suppl 2) , S4
- https://doi.org/10.1186/1471-2164-9-s2-s4
Abstract
To examine the usefulness of protein disorder predictions as a tool for the comparative analysis of viral proteins, a relational database has been constructed. The database includes proteins from influenza A and HIV-related viruses. Annotations include viral protein sequence, disorder prediction, structure, and function. Location of each protein within a virion, if known, is also denoted. Our analysis reveals a clear relationship between proximity to the RNA core and the percentage of predicted disordered residues for a set of influenza A virus proteins.Keywords
This publication has 69 references indexed in Scilit:
- Lessons Learned from Reconstructing the 1918 Influenza PandemicThe Journal of Infectious Diseases, 2006
- Evidence of an absence: the genetic origins of the 1918 pandemic influenza virusNature Reviews Microbiology, 2004
- Antibodies, viruses and vaccinesNature Reviews Immunology, 2002
- Design and tests of an HIV vaccineBritish Medical Bulletin, 2002
- Realities and enigmas of human viral influenza: pathogenesis, epidemiology and controlVaccine, 2002
- AIDS — The First 20 YearsNew England Journal of Medicine, 2001
- H1N1-influenza as Lazarus: Genomic resurrection from the tomb of an unknownProceedings of the National Academy of Sciences, 2001
- Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: an evolutionary link between negative-stranded RNA viruses and retroviruses.Journal of General Virology, 1999
- Structural biology of HIV 1 1Edited by P. E. WrightJournal of Molecular Biology, 1999
- Molecular biology and pathogenesis of animal lentivirus infections.1996