An improved synthesis of the antithyroid factor DL‐goitrin
- 1 January 1988
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 107 (3) , 132-133
- https://doi.org/10.1002/recl.19881070305
Abstract
DL‐1‐Amino‐3‐buten‐2‐ol HH2CCH‐CH(OH)‐CH2NH2 has been synthesized in a satisfactory overall yield by reduction of the protected cyanohydrin H2CCH‐CH(OR)‐CN [R = ‐CH(CH3)OC2H5] with aluminum hydride, followed by removal of the protecting group with aqueous hydrochloric acid and treatment with potassium hydroxide. The amino alcohol is a key intermediate in a synthesis of the antithyroid factor goitrin reported previously.Keywords
This publication has 2 references indexed in Scilit:
- Selective reductions. XII. Explorations in some representative applications of aluminum hydride for selective reductionsJournal of the American Chemical Society, 1968
- Synthesis of the Natural Antithyroid Factor l-5-Vinyl-2-thioöxazolidone1Journal of the American Chemical Society, 1950