Effect of baclofen on the .GAMMA.-motor activity in the rat.

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Abstract
The effect of baclofen on static .gamma.-activity enhanced by pinna pinching was compared with some of centrally acting muscle relaxants (chlorpromazine, mephenesin and diazepam) in the anesthetized rat. Baclofen (0.5-2 mg/kg, i.v.) showed only a little effect on the static .gamma.-activity. At a higher dose of 5 mg/kg, the drug showed a marked depressant effect on the static .gamma.-activity, although this dose was much higher than that required to depress spinal reflex activity. Chlorpromazine, mephenesin and diazepam depressed the static .gamma.-activity at lower doses than those required to depress spinal reflex activity. Apparently, the depressant action of baclofen on the static .gamma.-activity makes only a small contribution to the muscle relaxant action and therapeutic effectiveness of the drug.

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