Chlamydia trachomatis in non-specific urethritis.

Publisher Website
Google Scholar
Abstract
C. trachomatis was isolated from 58.5% of 159 patients with non-specific urethritis (NSU) using irradiated McCoy cell cultures. Patients with persistent Chlamydia-positive NSU remained Chlamydia-positive each time they were examined before treatment and patients with Chlamydia-negative NSU remained Chlamydia-negative during the course of the illness. Neither the duration of symptoms of urethritis nor a history of previous urethritis affected the chlamydial isolation rate significantly. Of 40 patients with severe discharge 30 (75%) harbored C. trachomatis. One-third of the Chlamydia-positive patients had a severe urethral discharge, while this was present in only 15% of Chlamydia-negative patients. Complications, such as conjunctivitis, arthritis and epididymitis, were more severe in men with Chlamydia-positive NSU than in those with Chlamydia-negative NSU. Of 64 men matched for sexual promiscuity but without urethritis, none harbored C. trachomatis in his urethra. This differs significantly (P < 0.001) when compared with patients with NSU. C. trachomatis was isolated from the urogenital tract in 24 (42%) out of 57 female sexual contacts of patients with NSU. The presence of C. trachomatis in the women correlated significantly (P < 0.001) with the isolation of the agent from their male contacts. These findings give further evidence for the etiological role of C. trachomatis in non-specific urethritis and its sexual transmission.
Keywords