Olfactory Neuroepithelioma: Review of the World Literature and Presentation of Two Cases

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Abstract
SINCE the first description of olfactory neuroepithelioma by Berger et al1 in 1924, there have been 102 subsequent cases reported in the world literature. That the tumor is not as uncommon as once believed is evidenced by more frequent recent reports of it. The main problem seems to have been one of recognition, and the literature is replete with instances of mistaken diagnoses. The olfactory neuroepithelioma is a notorious masquerader and has been mistaken for transitional cell carcinoma, malignant melanoma, plasmacytoma, myxosarcoma, reticulum cell sarcoma, and lymphosarcoma. By definition, the esthesioneuroepithelioma olfactif, according to Berger et al,1 is a malignant neoplasm of the olfactory apparatus with a histologic pattern similar to that of tumors of sympathetic ganglia, the adrenal medulla, and the retina. Previously unreported case histories of two patients and a comprehensive systematic review of the significant aspects of this lesion are presented in an endeavor

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