Effect of Vitamin E on Carcinogenicity of Methylcholanthrene.

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Abstract
Discussion and conclusions The C57 mice have a low incidence of spontaneous tumors, but respond uniformly well to carcinogens. Age does not seem to be a prominent factor, though more primitive sarcomas are produced in very young mice (10). Mineral oil and tricaprylin, if critically purified, apparently have little or no specific influence on carcinogenesis when used as a vehicle in a subcutaneous depot. Alpha tocopherol appreciably inhibited the carcinogenic activity of methylcholanthrene in the first experiment, and failed to produce tumors in the controls. In the second experiment, which had a bascially similar plan, though differing in the sex and substrain of mice, dosage of Vit. E, and vehicle used for the carcinogen, inhibition of the carcinogenic activity of methylcholanthrene by alpha tocopherol was confirmed. The significance of these results approximates the 93% level(11, 12).

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