Vasomotor control in healed grafted skin in humans

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Abstract
Do the vasomotor functions unique to skin recover in a skin graft? To determine whether locally mediated vasodilation and active reflex vasodilation recovery, we applied direct heating and whole-body heating, respectively. Also, presence of sympathetic cutaneous vasoconstriction was tested with application of lower body negative pressure (LBNP) during local heating. Subjects were six men who had been severely burned. Forearm blood flow (FBF) was recorded (venous occlusion plethysmography) in regions with healed split-thickness circumferential grafts. All subjects responded normally to local heating of the forearm (irrigation with 42 degrees C water). All but one showed cutaneous vasoconstriction in response to LBNP. Three subjects responded normally to whole-body heating with water-perfused suits (oral temperature elevation approximately 1.5 degrees C); two subjects had attenuated responses. No active vasodilation was normal cutaneous vasomotor functions return in (or under) split-thickness skin grafts, recovery and associated thermoregulatory function may be attenuated or absent, perhaps in relation to the survival of dermis.