The recognition of intravascular clotting. The plasma protamine paracoagulation test

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Abstract
The plasma protamine paracoagulation (3P) test for demonstrating fibrin monomer in citrated blood plasma has been useful in identifying diffuse intravascular coagulation in eight patients when evaluated in the light of clinical and other laboratory findings. The result of the 3P test is also postitive in some patients after open-heart surgery. Only two such patients, both children having repair of congenital heart defects, had evidences of a consumptive coagulopathy. Patients with venous thrombosis, possible pulmonary embolism, or both inconsistently had a positive 3P test result without other evidences of consumptive coagulopathy. The 3P test result was negative in one case each of primary fibrinolysis and of malignant hypertension.

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