Atrazine Inhibition of Carbofuran Metabolism in the House Cricket1

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Abstract
The metabolism of ring-labeled [14C] carbofuran was studied in Acheta domesticus (L.) which has been pre-exposed to 10, 20, and 30 ppm of atrazine for a month. Most of the carbofuran could be extracted from the cricket body. Excretion of carbofuran is not an important defense mechanism in the cricket. Degradation of carbofuran was inhibited in the presence of atrazine, especially when the concentration of atrazine was 30 ppm. The inhibition occurred at the level of the hydroxylation of cabofuran at its carbon-3 position. The results support the hypothesis that compounds capable of blocking the microsomal electron flow can potentate the toxicity of certain insecticides, possibly by inhibition of the microsomal detoxification process.

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