Inhibition of Growth of Mycobacterium tuberculosis by a Mold Product

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Abstract
An incompletely identified mold (fam. Aspergillaceae) was grown 14 days on a modified Czapek-Dox medium. The acidified filtrate was repeatedly extracted with ether and NaOH, and then pptd. with HC1. The antibiotic activity of the extract was tested against M. tuberculosis in test-tubes incubated at 37.5[degree]C for 5 to 14 days. Growth was partially or completely inhibited depending upon the potency of the extract. The extract showed little deterioration when incub. 2 wks. at 37.5[degree]C or when autoclayed at 15 lbs. for 15 min. It showed lowered activity when incub. with normal human serum or Sorensen phosphate buffer at pH 7.2 to 7.6.