Eph receptor signalling casts a wide net on cell behaviour
Top Cited Papers
- 1 June 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 6 (6) , 462-475
- https://doi.org/10.1038/nrm1662
Abstract
Eph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-anchored ligands, ephrins, at sites of cell-cell contact. Eph signals affect both of the contacting cells and can produce diverse biological responses. New models explain how quantitative variations in the densities and signalling abilities of Eph receptors and ephrins could account for the different effects that are elicited on axon guidance, cell adhesion and cell migration during development, homeostasis and disease.Keywords
This publication has 129 references indexed in Scilit:
- Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancerNature Genetics, 2004
- EphB1-mediated Cell Migration Requires the Phosphorylation of Paxillin at Tyr-31/Tyr-118Journal of Biological Chemistry, 2004
- Eph–ephrin promiscuity is now crystal clearNature Neuroscience, 2004
- Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signalingNature Neuroscience, 2004
- Ephrin signaling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signaling bind them?Life Sciences, 2003
- Eph/Ephrin Signaling Regulates the Mesenchymal-to-Epithelial Transition of the Paraxial Mesoderm during Somite MorphogenesisCurrent Biology, 2003
- Mutational Analysis of the Tyrosine Kinome in Colorectal CancersScience, 2003
- Mechanisms and functions of eph and ephrin signallingNature Reviews Molecular Cell Biology, 2002
- Crystal structure of an Eph receptor–ephrin complexNature, 2001
- Topographic Mapping from the Retina to the Midbrain Is Controlled by Relative but Not Absolute Levels of EphA Receptor SignalingCell, 2000