Prevention of endotoxin‐induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony

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Abstract
Bacterial endotoxin injected i.v. into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnea, dyspnea, hypoxemia, colic, lactic acidosis and diarrhea resulted from administration of 10 .mu.g/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.