Rapid Solid-phase Extraction/Derivatization System for Sample Preparation and Gas Chromatographic/Mass Spectrometric Determination of Drugs in Human Urine
- 15 February 1997
- journal article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 11 (3) , 298-306
- https://doi.org/10.1002/(sici)1097-0231(19970215)11:3<298::aid-rcm775>3.0.co;2-#
Abstract
A novel automatic system has been developed for the rapid solid-extraction and derivatization of different drugs and their metabolites from urine, prior to further analysis. Manual injection of underivatized/derivatized drugs in a GC/MS system, in which the quadrupole mass filter was operated conventionally, provided high sensitivity and selectivity at the selected m/z value. The precision (2.1-6.8%) is acceptable and the overall recovery from urine was determined to be ca. 95%. The effectiveness of this approach is demonstrated with data obtained from different urine samples which had tested positively.Keywords
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