Normal ranges of the activities of ten different enzymes in 100 independent preparations of chorionic villi. Comparison of specimens from induced abortions, biopsies, and cultured cells
- 1 March 1989
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 9 (3) , 195-204
- https://doi.org/10.1002/pd.1970090309
Abstract
In order to obtain a large set of normal control values, the activities of three cytosolic enzymes of purine metabolism and seven lysosomal enzymes were determined in homogenates of chorionic villi derived from induced abortions of normal pregnancies (7th–12th week) in about 100 individual cases. Possible reasons for the rather wide ranges of normal distributions of enzyme activities are discussed. The values are compared: (1) with available data in the literature; (2) with activities determined in decidual homogenates prepared from the same samples; (3) with activities of cells of cultures established and grown from villi in the same samples; and (4) with enzyme activities measured in chorionic biopsies using the same methods. Implications for the prenatal diagnosis of the associated metabolic diseases are considered.Keywords
This publication has 24 references indexed in Scilit:
- First trimester diagnosis of adenosine deaminase deficiencyPrenatal Diagnosis, 1987
- Worldwide Experience with First-Trimester Fetal Diagnosis by Molecular AnalysisPublished by Springer Nature ,1987
- Comparative study of 15 lysosomal enzymes in chorionic villi and cultured amniotic fluid cells. Early prenatal diagnosis in seven pregnancies at risk for lysosomal storage diseasesPrenatal Diagnosis, 1985
- Prenatal diagnosis of glycogenosis type II (Pompe's disease) using chorionic villi biopsyClinical Genetics, 1985
- Activity of 30 Nonlysosomal Enzymes in Chorionic VilliPublished by Springer Nature ,1985
- Comparison of the Activities of 15 Lysosomal Enzymes in Chorionic Villi and in Cultured Amniotic Fluid CellsPublished by Springer Nature ,1985
- First Trimester Fetal Diagnosis: Principles and Potential Pitfalls in Enzymatic and Molecular DiagnosesPublished by Springer Nature ,1985
- FIRST-TRIMESTER DIAGNOSIS OF LESCH-NYHAN SYNDROMEThe Lancet, 1984
- Activity and multiple forms of α‐L‐fucosidase and hexosaminidase in chorion biopsy specimens and some fetal organsPrenatal Diagnosis, 1984
- Human amniotic fluid cells grown in a hormone-supplemented medium: suitability for prenatal diagnosis.Proceedings of the National Academy of Sciences, 1982