CLINICAL PHARMACOKINETICS OF BUPROPION - A REVIEW

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (5) , 82-84
Abstract
The antidepressant bupropion is absorbed rapidly after single-dose oral administration of tablets, capsules or aqueous solution of the hydrochloride salt to volunteers. Peak bupropion plasma concentrations are generally attained within 2 h, followed by a biphasic decline. The half-life of the initial (.alpha.) phase is .apprx. 1.5 h and that of the 2nd (.beta.) phase is .apprx. 14.0 h. An oral dose of bupropion is subjected to extensive 1st-pass metabolism. The ratio between plasma clearance and fraction absorbed (.apprx. 2 l/h per kg) is consistent within the 50-250 mg single dose range.