Ubiquitylation of RAG-2 by Skp2-SCF Links Destruction of the V(D)J Recombinase to the Cell Cycle
- 1 June 2005
- journal article
- research article
- Published by Elsevier in Molecular Cell
- Vol. 18 (6) , 699-709
- https://doi.org/10.1016/j.molcel.2005.05.011
Abstract
No abstract availableKeywords
This publication has 38 references indexed in Scilit:
- Mechanism and regulation of human non-homologous DNA end-joiningNature Reviews Molecular Cell Biology, 2003
- RAG2 Is Down-regulated by Cytoplasmic Sequestration and Ubiquitin-dependent DegradationJournal of Biological Chemistry, 2002
- V(D)J Recombination: RAG Proteins, Repair Factors, and RegulationAnnual Review of Biochemistry, 2002
- Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to TranslocationsCell, 2002
- Genetic Analysis of the DNA-dependent Protein Kinase Reveals an Inhibitory Role of Ku in Late S–G2 Phase DNA Double-strand Break RepairJournal of Biological Chemistry, 2001
- Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplicationThe EMBO Journal, 2000
- DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformationNature, 2000
- p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27Current Biology, 1999
- A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell CycleImmunity, 1996
- Regulation of V(D)J Recombination Activator Protein RAG-2 by PhosphorylationScience, 1993