Photochemical Synthesis of Spirocyclohexylisoquinolines, Analogues of (±)-Galanthamine and (±)-Lycoramine
- 1 February 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (3) , 453-466
- https://doi.org/10.1080/00397919708006047
Abstract
Photocyclization of N-arylenamides 10, 15 and 16 led efficiently to spirotricyclic δ-lactams 5, 6 and 7. Compound 7 was easily and stereospecifically transformed in two steps into spirocyclohexylisoquinolines 3 and 4 which show structural analogies with some Amaryllidaceae alkaloids, galanthamine 1 and lycoramine 2.Keywords
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