EFFECTS OF AMYLOID INDUCTION ON PLASMA-PROTEIN TURNOVER, AND ITS IMPLICATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 83  (2) , 299-+
Abstract
Using polyacrylamide gel electrophoresis and radioiodinated plasma proteins, data on the rate constant for synthesis and fractional degradation rates for albumin, .alpha.1-, .alpha.2-, .beta.-, and .gamma.-globulins were obtained during accelerated amyloid induction in a murine model. During amyloid induction there is an increased rate of synthesis of .alpha.2-, .beta.-, and .gamma.-globulins but only the .alpha.2-globulin degradation rate is accelerated. In this exprimental system, should amyloid protein be a degradation product of a plasma fraction, the .alpha.2-globulin appears as the most likely precursor. The implications of these findings are discussed, and a new general mechanism of amyloid production is proposed.