Amperometric Detection of Glucose Released from Imune Lysis of Glusoce Loaded Liposome

Abstract
Glucose released from complement mediated immunospecific damage to glucose loaded liposomes sensitized with lipid antigens was detected by an amperometric glucose enzyme electrode to devise a simple method for electrochemical immunoassay. This method involves the indirect determination of antibody and complement levels by measurement of the released glucose. The results obtained for rabbit and guinea pig serum were correlated with those obtained by spectrophotometry with excellent accuracy, indicating that the amperometric enzyme electrode can be another substitute for the spectrophotometric detection of glucose released from immune lysis of liposome loaded with glucose.