Porcine Endogenous Retrovirus Transmission Characteristics of an Inbred Herd of Miniature Swine
Open Access
- 15 March 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (6) , 3045-3048
- https://doi.org/10.1128/jvi.76.6.3045-3048.2002
Abstract
Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.Keywords
This publication has 25 references indexed in Scilit:
- The Porcine Endogenous Retrovirus Long Terminal Repeat Contains a Single Nucleotide Polymorphism That Confers Distinct Differences in Estrogen Receptor Binding Affinity between PERV A and PERV B/C SubtypesVirology, 2001
- Productive Infection of Human Primary Cells and Cell Lines with Porcine Endogenous RetrovirusesVirology, 2001
- Comparison of Replication-Competent Molecular Clones of Porcine Endogenous Retrovirus Class A and Class B Derived from Pig and Human CellsJournal of Virology, 2001
- Risk of zoonosis in xenotransplantationTransplantation Proceedings, 2000
- New risks, new gainsNature, 2000
- Establishment and Characterization of Molecular Clones of Porcine Endogenous Retroviruses Replicating on Human CellsJournal of Virology, 2000
- Xenotransplantation from swine: making a list, checking it twice…Xenotransplantation, 2000
- Infection Hazards of XenotransplantationJournal of Infection, 2000
- Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cellsThe Lancet, 1998
- Infection of human cells by an endogenous retrovirus of pigsNature Medicine, 1997