A New Phenoxyacetate-Based Linker System for the Solid-Phase Synthesis of Oligosaccharides
- 15 February 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (5) , 747-750
- https://doi.org/10.1021/ol007062e
Abstract
A novel linker system has been designed, and its first application to solid-phase oligosaccharide synthesis is described. The use of the highly reactive o-nitro-phenoxyacetate linker allows a fast and quantitative cleavage using mild basic conditions. This method combined with the trichloroacetimidate glycosylation exhibits highly promising results as demonstrated for the synthesis of tetrasaccharide 1 (n = 3) containing glucose β(1 → 4) and β(1 → 6) linkages.Keywords
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