Fetal mortality in oral cleft families: data from Indiana and Montreal

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Abstract
Analysis of 418 sibships of oral clef probands from Indiana, and 288 sibships from Montreal indicate that the incidence of fetal mortality is significantly greater in sibships of probands with cleft lip and cleft palate (CLP) as compared to that in sibships or probands with cleft lip (CL) alone. A multifactorial-2-threshold concept is supported, according to which a lower level of liability results in clefting whereas a higher level of liability causes fetal deaths. They add confirmatory evidence in support of earlier work, utilizing data from 2 different sources.