Herpes Simplex Virus Type 2 and Acute Aseptic Meningitis: Clinical Features of Cases with Isolation of Herpes Simplex Virus from Cerebrospinal Fluids

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Abstract
Herpes simplex virus (HSV) was recovered from the cerebrospinal fluids (CSF) of 10 patients with acute aseptic meningitis. HSV type 1 was isolated from the CSF of a 6-mo.-old boy. The other 9 HSV isolates from CSF were from adults aged 15-29 yr, 7 of these isolates were available for typing and were identified as HSV type 2. In 9 other patients with acute aseptic meningitis and belonging to the same age-group, a HSV infection was suggested by a significant titer rise in complement-fixing antibodies against HSV. The clinical features of the 10 patients with HSV isolation from CSF are presented. The 6-mo.-old boy with HSV type 1 had an acute benign aseptic meningitis. Seven of the 9 adults with HSV type 2 had acute uncomplicated aseptic meningitis, 1 had an acute meningoencephalitis and 1 (isolate untyped) an acute meningomyelitis.