Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis
Open Access
- 1 August 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (8) , 3175-3178
- https://doi.org/10.1128/aac.48.8.3175-3178.2004
Abstract
The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.Keywords
This publication has 26 references indexed in Scilit:
- Mechanisms of drug resistance in mycobacterium tuberculosisFrontiers in Bioscience-Landmark, 2004
- EfrAB, an ABC Multidrug Efflux Pump in EnterococcusfaecalisAntimicrobial Agents and Chemotherapy, 2003
- Molecular Cloning and Characterization of an ABC Multidrug Efflux Pump, VcaM, in Non-O1 Vibrio choleraeAntimicrobial Agents and Chemotherapy, 2003
- Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosisBiochemical Journal, 2002
- CmeABC Functions as a Multidrug Efflux System in Campylobacter jejuniAntimicrobial Agents and Chemotherapy, 2002
- Prediction of Drug Resistance in M. tuberculosis: Molecular Mechanisms, Tools, and ApplicationsIUBMB Life, 2002
- Efflux in bacteria: what do we really know about it?Expert Opinion on Investigational Drugs, 2001
- Characterization of P55, a Multidrug Efflux Pump in Mycobacterium bovis and Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 2001
- Contribution of the multidrug efflux pump LfrA to innate mycobacterial drug resistanceFEMS Microbiology Letters, 2000
- The ATP binding cassette (ABC) transport systems ofMycobacterium tuberculosisFEMS Microbiology Reviews, 2000