Relationship between arterial and venous bicarbonate values

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Abstract
The clinical efficacy of using the venous CO2 value as obtained with routine electrolytes in acid-base management was determined. Venipuncture samples for venous CO2 content and chloride concentrations were obtained in 336 patients with arterial blood pH, PaO2 (arterial partial pressure of O2), PaCO2 (arterial partial pressure of CO2), and O2 saturation determinations. The linear correlation between actual calculated arterial .**GRAPHIC**. and the measured venous CO2 was significant (P < .001). Using venous CO2, chloride, and arterial pH values, various prediction equations for estimating arterial .**GRAPHIC**. are presented. The effects of time delay, exposure to air, and acute changes in arterial blood pH and PaCO2 on venous CO2 levels were determined. Venous CO2 determinations should not be substituted for the arterial .**GRAPHIC**. value in the Henderson-Hasselbalch equation to calculate arterial blood pH or PaCO2. Clinically, the venous CO2 value has little direct use, but when venous CO2 content is abnormal, it should alert the clinician to the need for obtaining arterial blood gas and pH values.

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