Mutant of Salmonella typhimurium LT2 deficient in DNA adenine methylation

Open Access

1 July 1986

journal article
research article
Published by American Society for Microbiology in Journal of Bacteriology

Vol. 167 (1) , 420-422
https://doi.org/10.1128/jb.167.1.420-422.1986

Abstract

A mutant of Salmonella typhimurium LT2 deficient in methylation of the adenine residues in the sequence 5'-GATC-3' was isolated. The mutation (dam-1) was linked to the cysG locus, and the properties of the mutant were similar to those of Escherichia coli dam mutants. Reversion of the hisC3076 frameshift marker by 9-aminoacridine was substantially enhanced by the dam-1 mutation, implying a direct role for adenine methylation in the prevention of frameshift mutation induction.

This publication has 14 references indexed in Scilit:

Frameshift mutagenesis of lambda prophage by 9-aminoacridine, proflavin and ICR-191
Molecular Genetics and Genomics, 1984
Induction of SOS functions is not recquired for recA+-dependent mutagenicity of 9-aminoacridine in Salmonella typhimurium strain trpE8
Mutation Research/DNA Repair Reports, 1984
Methodologies for the determination of various genetic effects in permeable strains of E. coli K-12 differing in DNA repair capacity Quantification of DNA adduct formation, experiments with organ homogenates and hepatocytes, and animal-mediated assays
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1984
Methylation of Prokaryotic DNA
Published by Springer Nature ,1984
The Isolation and Characterization of theEsherichia ColiDNA adenine methylase(dam)gene
Nucleic Acids Research, 1983
Methylation-Instructed Mismatch Correction as a Postreplication Error Avoidance Mechanism in Escherichia Coli
Published by Springer Nature ,1982
Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction.
Proceedings of the National Academy of Sciences, 1980
Induced mutagenesis in dam − mutants of Escherichia coli: A role for 6-methyladenine residues in mutation avoidance
Molecular Genetics and Genomics, 1978
Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
Mutation Research/Environmental Mutagenesis and Related Subjects, 1975
Location of DNA methylation genes on the Escherichia coli K-12 genetic map
Molecular Genetics and Genomics, 1973