ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia
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Open Access
- 1 May 2003
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 348 (18) , 1764-1775
- https://doi.org/10.1056/nejmoa023143
Abstract
The mutational status of immunoglobulin heavy-chain variable-region (IgVH ) genes in the leukemic cells of chronic lymphocytic leukemia (CLL) is an important prognostic factor in the disease. We investigated whether the expression of ZAP-70 by CLL cells correlated with the IgVH mutational status, disease progression, and survival.Keywords
This publication has 33 references indexed in Scilit:
- Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemiaBlood, 2002
- Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemiaBlood, 2002
- Genetics of chronic lymphocytic leukemia: genomic aberrations and VH gene mutation status in pathogenesis and clinical courseLeukemia, 2002
- Classical and new prognostic factors in chronic lymphocytic leukemia: Where to now?The Hematology Journal, 2002
- Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic LeukemiaThe Journal of Experimental Medicine, 2001
- Clonal selection and learning in the antibody systemNature, 1996
- The human immunoglobulin VH repertoireImmunology Today, 1995
- The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoireImmunology Today, 1994
- Association of a 70‐kDa tyrosine phosphoprotein with the CD16:ζ:γ complex expressed in human natural killer cellsEuropean Journal of Immunology, 1993
- ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chainCell, 1992