Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy
- 9 May 2000
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 54 (9) , 1856-1859
- https://doi.org/10.1212/wnl.54.9.1856
Abstract
Article abstract The authors enrolled 1,029 patients with CD4 counts ≤ 200/μL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.Keywords
This publication has 9 references indexed in Scilit:
- Antiretroviral drugs and the central nervous systemAIDS, 1998
- Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus InfectionNew England Journal of Medicine, 1998
- Randomised placebo-controlled trial of ritonavir in advanced HIV-1 diseaseThe Lancet, 1998
- A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or LessNew England Journal of Medicine, 1997
- Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV DiseaseScience, 1997
- Diagnosis of central nervous system complications in HIV-infected patientsAIDS, 1997
- Temporal trends in the incidence of HTV‐1‐related neurologic diseasesNeurology, 1994
- Zidovudine treatment of the AIDS dementia complex: Results of a placebo‐controlled trialAnnals of Neurology, 1993
- Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus‐type 1 (HIV‐1) infectionNeurology, 1991