Experimental gastric ulcers in the rat: The separate and combined effects of vagotomy and bile-duct implantation into the stomach

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Abstract
Erosions and ulcers of the gastric mucosa have been produced in rats by implanting into the stomach the lower bile-duct carrying bile and pancreatic juice or the upper bile-duct carrying bile only. Vagotomy did not produce gastric lesions in this series. Vagotomy did not increase the incidence of gastric lesions when it was combined with implantation of the bile-duct into the stomach. These results suggest that, if both current theories of the cause of gastric ulceration have some validity, their actions are mediated through separate mechanisms and do not augment each other.
Funding Information
  • British Medical Association
  • Department of Pathology