Enantioselective Synthesis of Differently Protected 1,2-Diamines via α-Alkylation of Dibenzylaminoacetaldehyde SAMP-Hydrazone
- 1 January 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1996 (01) , 53-58
- https://doi.org/10.1055/s-1996-4166
Abstract
Chiral, unsymmetrically and differently protected 1,2-diamines 4 were prepared in moderate to good overall yields and with high asymmetric inductions (ee = 91-99%) by α-alkylation of N,N-dibenzylaminoacetaldehyde SAMP-hydrazone (S)-2 with subsequent oxidative cleavage to the corresponding α-aminonitriles, reduction to the diamines, and protection of the latter.Keywords
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