Protein Analysis in Cerebrospinal Fluid
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 33 (2) , 134-142
- https://doi.org/10.1159/000116920
Abstract
To examine the possible influence of the blood-CSF barrier function on mathematical formulas for estimating intrathecal IgG production {IgG index, Tourtellotte’s formula [TOURT], Schuller and Sagar’s formula [Schull], and Reiber and Felgenhauer’s formula [IgG(loc)]}, we analysed serum and CSF samples from 105 healthy individuals, aged 18-88 years, and 816 consecutive patients without oligoclonal IgG bands (OCBs) in the CSF, aged 18-91 years. In healthy individuals there was no significant correlation between the CSF/serum (S) albumin ratio (i.e. blood-CSF barrier function) and the IgG index, a dimensionless quotient for determining intrathecal IgG production, and only a small correlation (r = –0.08, pKeywords
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