Limitations of the single sample tracer method for determining glomerular filtration rate

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Abstract
Apparent volumes of distribution of 51Cr-EDTA and 99Tcm-DTPA [diethylene triamine pentaacetic acid] were calculated 3 h after i.v. injection and correlated with simultaneous estimation of GFR [glomerular filtration rate]. A reasonable correlation between these values was obtained for those patients with GFR > 50 ml/min (standard error of estimate using 51Cr-EDTA 7.6 ml/min and 99Tcm-DTPA 13.7 ml/min). Theoretical reasons are given why a single sample technique will not be accurate over a wide range of renal function.