Absorption, Elimination and Excretion of Orally Administered Vitamin B12in Normal Subjects and in Patients with Pernicious Anemia

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Abstract
A SELECTIVE defect of Vitamin B12 absorption is pathogenic of Addisonian pernicious anemia. The parenteral administration of crystalline vitamin B12 in daily doses of 1 to 5 microgm. to patients with pernicious anemia in relapse has been shown to produce a characteristic, optimal hematopoietic response.1 2 3 4 5 Oral administration of crystalline vitamin B12 in daily doses of 5 microgm. to patients with pernicious anemia in relapse produces little or no hematopoietic response unless a source of intrinsic factor is administered either simultaneously or within six hours.6 , 7 This persistent inability of patients with Addisonian pernicious anemia to absorb from the . . .