The Anti-Allergic Activity of Benoxaprofen [2-(4-Chlorophenyl)-α-Methyl-5-Benzoxazole Acetic Acid] – A Lipoxygenase Inhibitor

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Abstract
Benoxaprofen [2-(4-chlorophenyl)-α-methyl-5-benzoxazole acetic acid], a novel anti-inflammatory compound, is also an orally-active anti-allergic compound in animals. It reduced the anaphylactic release of mediators, particularly slow-reacting substance of anaphylaxis (SRS-A), from both in vitro and in vivo animal models. Benoxaprofen marginally antagonized the activity of histamine on the guinea pig ileum, but not of SRS-A, at concentrations which inhibited the release of SRS-A.

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