A synthesis of 25‐hydroxycholecalciferol‐(26, 27‐3H)
- 1 April 1973
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 9 (2) , 339-346
- https://doi.org/10.1002/jlcr.2590090218
Abstract
The synthesis of 25‐hydroxycholecaleiferol‐(26, 27‐3H) is described. 25‐Oxo‐27‐norcholesta‐5, dien‐3β‐yl acetate is converted photochemically to 25‐oxo‐27‐norcholecalciferol‐3‐acetate, which is then reacted with tritiated methylmagnesium iodide and subsequently saponified to give 25‐hydroxycholecalciferol‐(26, 27‐3H).Keywords
This publication has 12 references indexed in Scilit:
- Photochemie in der Vitamin D-Reihe. II. Die Wellenlängenabhängigkeit der Photoisomerisationen des PräcalciferolsHelvetica Chimica Acta, 1972
- Recent advances in vitamin D metabolismClinics in Endocrinology and Metabolism, 1972
- Synthesis of [26,27-3H]-25-hydroxycholecalciferolAnalytical Biochemistry, 1971
- Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium MetabolismNature, 1971
- Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteNature, 1970
- “Activation” of vitamin D by the liverJournal of Clinical Investigation, 1969
- In vitro production of 25-hydroxycholecalciferolBiochemical and Biophysical Research Communications, 1969
- Investigations on sterols. XXXV: Synthesis of 25‐hydroxycholecalciferol (Short communication)Recueil des Travaux Chimiques des Pays-Bas, 1969
- 25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3Biochemistry, 1968
- Studies on vitamin D and related compounds III. Short communication on the cis‐trans isomerization of calciferol and the properties of “trans”‐vitamin D2Recueil des Travaux Chimiques des Pays-Bas, 1955