Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism
Open Access
- 1 June 1992
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 106 (2) , 231-232
- https://doi.org/10.1111/j.1476-5381.1992.tb14321.x
Abstract
Cannabinoid receptor ligands irreversibly inhibited peak voltage-activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin-sensitive. Inhibition was largely due to a reduction in the ω-conotoxin sensitive portion of high-voltage activated (HVA) current, although there was also a significant decrease in low-voltage activated current (56%) and in the nifedipine-sensitive portion of HVA current (41%).Keywords
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