Interactions of inflammatory mediators and low pH not influenced by capsazepine in rat cutaneous nociceptors
- 1 April 2000
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 11 (5) , 973-976
- https://doi.org/10.1097/00001756-200004070-00015
Abstract
The rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotonin and prostaglandin E2. Only synchronous application of protons and mediators resulted in a significant nearly three-fold augmentation of the nociceptive pH response, and capsazepine (10(-5) M) did not block this short-lived enhancement. Thus, it does not seem to involve the capsaicin receptor (VRI) which is in contrast to a previous finding from cultured sensory neurons.Keywords
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