Ganglioside complexes as new target antigens in Guillain–Barré syndrome

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Abstract
Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain–Barré syndrome (GBS) by the use of enzyme‐linked immunosorbent assay and thin‐layer chromatogram immunostaining. Those sera also had antibody activities to such ganglioside complexes as GD1a/GM1, GD1b/GT1b, and GM1/GT1b but had little or no reactivity to the each isolated antigen. Clustered epitopes of the ganglioside complex in the plasma membrane may be targeted by such an antibody, and interaction between the antibody and ganglioside complex may induce the neuropathy. Ann Neurol 2004
Funding Information
  • Ministry of Education, Culture, Sports, Science and Technology of Japan(Grants-in-Aid for Scientific Research) (14570581, 16590854)
  • Research Grant for Neuroimmunological Diseases
  • Ministry of Health, Labour, and Welfare of Japan (Health Sciences Research Grant on Psychiatric and Neurological Diseases and Mental Health) (H15-015)