E‐selectin expression in salivary endothelial cells and sera from patients with systemic sclerosis
Open Access
- 1 March 1995
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 38 (3) , 406-412
- https://doi.org/10.1002/art.1780380318
Abstract
Objective. To assess endothelial cell activation in patients with systemic sclerosis (SSc). Methods. Concomitant study of salivary gland biopsy tissues and sera for expression of E-selectin and its potent activator tumor necrosis factor α (TNFα), using immunostaining and enzyme-linked immunosorbent essay. Results. E-selectin was overexpressed in SSc patients, but not in controls. TNFα was detected in mast cells. Conclusion. Mast cell–derived TNFα may contribute to endothelial cell activation in SSc.Keywords
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