Synthesis of nitric oxide by the haemocytes of the American horseshoe crab ( Limulus polyphemus )

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Abstract
Nitric oxide (NO) synthase, the enzyme responsible for the production of NO from L-arginine, is present in haemocytes of the American horseshoe crab ( Limulus polyphemus ). The synthesis of NO results in down-regulation of the aggregatory function of these cells in a manner similar to that previously described for mammalian platelets. These data indicate that formation of NO from L-arginine is a pathway of early evolutionary origin.