A rapid method for the diagnosis of acute uric acid nephropathy

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Abstract
Acute uric acid nephropathy is a reversible type of renal failure that results from deposition of uric acid crystals in the collecting tubules. A number of laboratory tests in 5 patients were compared with a clinical diagnosis of this disorder and 27 patients with acute renal failure of other causes. Neither the serum creatinine, BUN [blood urea N], serum urate concentrations, nor the ratio of serum urate:BUN differentiated between these 2 groups of patients. The ratio of uric acid to creatinine concentration on a random urine specimen differentiated between these 2 patient populations. All patients with uric acid nephropathy had a ratio greater than 1.0, while all patients with other types of acute renal failure had ratios of less than 1.0.