Resistance of Trypanosoma evansi to quinapyramine, suramin, stilbamidine and tryparsamide and analysis of cross-resistance
- 1 January 1971
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 65 (3) , 352-357
- https://doi.org/10.1016/0035-9203(71)90013-7
Abstract
A strain of T. evansi was made drug-fast to quinapyramine, suramin, stilbamidine and tryparsamide, respectively by treating mice with gradually increasing subcurative doses, passage of the relapse strain, and so on. The resistance exhibited to neutral aromatic arsenicals, melaminyl compounds, derivatives of acridine, diamidine and phenanthridine, and quinapyramine and suramin was analysed.Keywords
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- The preparation of a strain of Trypanosoma rhodesiense resistant to stilbamidine and some observations on its natureExperimental Parasitology, 1955