Eosinophils stimulate fibroblast DNA synthesis
Open Access
- 1 August 1987
- journal article
- Published by American Society of Hematology in Blood
- Vol. 70 (2) , 572-574
- https://doi.org/10.1182/blood.v70.2.572.572
Abstract
Fibrosis complicates a number of chronic inflammatory diseases and occurs in some conditions following chronic hypereosinophilic syndromes. We assessed whether eosinophils might be a source of fibrogenic factors. Extracts of human and guinea pig cell populations enriched for eosinophils contained substances that stimulated tritiated thymidine incorporation by human fibroblasts. Supernatants derived from resting eosinophils and extracts prepared from eosinophil granules also contained fibrogenic factors. Our findings demonstrate a new potential role for eosinophils and suggest a causal relationship between tissue eosinophilia and scar formation in certain parasitic condition.Keywords
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